Rare human disease found in dogs

A rare, severe form of pulmonary hypertension, which up until now, has only been classified as a human lung disease, has also been discovered in dogs according to a Michigan State University study.
"Our research is the first to document the existence of pulmonary veno-occlusive disease, or PVOD, in dogs," said Kurt Williams, the lead author of the study and an expert in respiratory pathology in MSU's College of Veterinary Medicine. "PVOD is considered one of the most severe forms of pulmonary hypertension."
The study is published in the journal Veterinary Pathology logy.
The number of pulmonary hypertension, or PH, cases reported in the United States is low, affecting 15 to 50 people per million each year. PVOD is diagnosed in only about 10 percent of PH cases where no other cause of the disease has been determined. Unfortunately, there are very few effective treatment options for PVOD and a lung transplant often becomes the best choice.
"PVOD might be more common in dogs than in people, but this has yet to be determined and needs to be looked at further," Williams said.
Pulmonary hypertension develops because of abnormal blood vessels in the lungs, which makes it harder for the heart to push blood through and provide oxygen to the rest of the body. In cases of PVOD, the small veins in the lungs become blocked, increasing pressure in these blood vessels, and ultimately causing heart failure.
"The same process happens in canines," Williams said. "These dogs also come in with similar symptoms as humans, yet because subtle changes in health may not be recognized as quickly in dogs, death can occur quickly once the animal is seen by a veterinarian."
Symptoms include cough, increased rate of breathing, respiratory distress, loss of appetite and chronic fatigue. Fatal progression of the disease in humans can last up to two years.
"PVOD is a poorly understood disease not just because it's so rare, but also because there've been no other animals known to have the disease," Williams said. "Our finding changes things."
Williams said that the discovery could be important for human medicine because the canine disease may serve as a model for human PVOD.
"It's cases like this that help to remind us how important veterinary medicine is to medicine in general," he said. "Our colleagues in the human medical community are becoming much more aware of the many diseases shared by our respective patients and how together we can learn from each other."

Longrich Business Opportunity - Grow At Your Own Pace

This is welcoming you to Longrich GLOBAL TEAM, the team comprise of highly enterprising men and women from all walks of life, across diff races whose common goal is to enrich their lives through a highly exciting and rewarding biz opportunity. Its all about considering an alternative income option, a plan B, that will supplement your present source of income, thereby eliminating the high risk associated with having a single source of income.
We therefore introduce LONGRICH, Chinese coy Established in 1986. has been in existence for 29 yearrs, with its research and development institutions in America, Japan, France & China. Longrich holds a wide variety of household cleaning products, personal care products, healthcare products and oral care products. Longrich is known for product quality, that’s why they manufacture products under OEM (Original Equipment Manufacturer). Longrich is the largest and most advanced centre for the research, development, manufacture and sales of cosmetics and healthcare products in china, with their products in over 50 countries of the world. The coy's visionary Chairman Zu Zhiwei is one of China's top Entrepreneurs. The Company is rated 42nd in 2014 Direct selling news (DSN) top 100 mlm companies in the world
Longrich manufactures top quality fast moving unique and highly effective products like Superbklean Anion sanitary napkins and pantyliners, Mosquito repellant sprays, Bamboo soaps, toothpaste, Antiperspirant, energy cup, classy style energy cups,Sheep placenta SOD body cream, Herbal body wash, mouthfreshners, handcream,wine, calcuim, Nutriv instant drink, cordycep coffe etc.
HOW DO YOU BECOME A DISTRIBUTOR: Now to become a distributor and benefit from this great biz opportunity
ENTRY LEVELS
POSITION/STATUS POINT VALUE (PV) PERFORMANCE BONUS % AMOUNT
VIP 1680PV
12%
N580,000 (earn 1% share of global sales)
PLATINUIM 720PV
12%
N255,000
GOLD 240PV
10%
N85,000
SILVER 120PV
8%
N45,000
You are allowed to select products of your choice worth your money
The catch is in achieving financial freedom through this opportunity offered by Longrich, if you decide to become a distributor.
Longrich distributes its innovative products through highly motivated independent distributors using networking marketing method, but unlike other network marketing coys it offers greater profitability and flexibility
BENEFITS OF LONGRICH
1. Maximum of 3 legs
2. No time frame (no pressure)
3.No compulsory monthly purchases (target)
4. Weekly bonus payment {green Thursday}
5. Grow at your own pace
6.Unlimited accumulation of bonus points
7. Leadership easily achieved.
PROMOS
Apart from bonuses paid directly into ur account every week based on your team's volume
TRAVELS: The coy organizes minimum of three 'all expense paid' international trips annually for qualifying distributors.
CAR: There is yearly Car promos, longrich has awarded over 100 brand new cars within its first 2 years!
HOUSE: 25Million house money is awarded from Star Director level
You are simply expected to bring in 3 people when you join, with the support offered by the team/club, those 3 people are taught , trained and encouraged to each duplicate to get their own 3, the business is fun extremely exciting and rewarding.
BONUSES
1. Performance bonus: Your entry status as silver(8%),gold (10% ) or Platinum/vip(12%) determines your earnings power, PB is paid weekly on all generations to infinity
2. Development bonus: (10% flat) paid on 2 of the highest Points per level the bonus leg.
3. Leadership bonus:(10% - 45%) paid on sponsorship tree up to 12th generation according to ur level/ranking
4. Retail order bonus: (25%- 50%) paid on retail/repeat orders
INCENTIVES
1. Platinum VIP incentive: (earn 1% of longrich global sales every cycle, can be converted to travel/car/house
2. Worldwide incentive: (earned from Diamond 4 level and above)2.5% of coy global sales
3: Star directors worldwide Incentive: (earn 2.5% of coy's Global
The earnings potential in dis biz is huge, all dat is required is DRIVE, PASSION, PERSISTENCE, ACTION. The earnings percentages increases as you move up the marketing plan unlike in other networks that it decreases, ur earnings increases and explodes as your team grows, that’s why its possible for a distributor who has only been in d biz for only 6 months to earn 4m monthly, Qualify forvtripscand cars.... performance bonus is paid on all generations till infinity. The compensation is Superb and highly generous, and will lead to true financial freedom but you must WORK to achieve it, if you wait for a perfect condition will never get started, the best time to start is NOW.....

3 Ways the Be-Everywhere Strategy Leads You Nowhere
When you first begin your journey as an online entrepreneur, you are quickly introduced to a number of experts, gurus and even a few ninjas. All of them offering actionable advice for those trying to succeed in their quest of pursuing the work they love.
You find yourself quickly soaking up all you can from the multitude of podcasts, blogs, and free eBooks -- listening and reading voraciously as your thoughts dance with possibility.
But then you come across two very powerful, yet dangerous, words.
These two words form the basis of much of the guru teachings and remain one of the most repeated strategies recommended for online entrepreneurs today.
“Be Everywhere."
This simple mantra means if you want to build your audience, and truly make an impact in the world, you have to literally be everywhere.
You should have a blog, launch a podcast, self-publish eBooks, create a course, guest post, create YouTube videos, and of course, be omnipresent on as many social media platforms as possible, including Twitter, Facebook, Google+, Pinterest, Instagram, LinkedIn, Snapchat…you get the idea.
While the two words, “be everywhere”, seem innocent enough, they may actually wreak havoc on your blossoming online business.
Here are three ways the Be Everywhere strategy actually leads you nowhere.
Related: Top 20 Social-Media Tools to Add to Your Arsenal in 2016
1. Leads you down multiple rabbit holes.
As a participant in the online business space, you have no doubt witnessed the rise (and fall) of various social media platforms and tools.
Each of these promises a new way to accomplish common tasks or mechanisms to ultimately grow your audience. You believe as part of the Be Everywhere strategy that you need to not only explore each of these platforms but you actually need to be an influencer on each.
You quickly get caught up in a game of whack-a-mole as each month seems to bring a new platform or player.
You jumped on the Vine bandwagon because simply everyone else was.
You heard you needed to start a podcast, so you did.
You heard about blab.im and figured that is where you needed to take your message.
You see everyone with a Snapchat image as their Facebook profile pic and you head over to Snapchat to join the herd.
Just as you start to exhale and absorb your fragile success, you see a status message from someone on Facebook that says, “Hey, are you on Anchor yet? Let’s connect."
Being everywhere literally takes you down so many paths that you often find yourself dazed and confused.
Each platform requires a learning curve. Each requires time and effort to determine exactly how you can leverage it. Each requires you to start anew in audience building and content creation.
And here’s the real kicker. Each ultimately drives you away from doing the work that truly matters in growing your business.
Instead of dominating distinct channels, you are distracted and disillusioned with unknown opportunity. You are pulled in so many directions that you actually neglect the work that will drive your business forward.
I’m not advocating for burying your head in Facebook and never exploring new and exciting platforms. You just need to be realistic when it comes to thinking you can effectively leverage each and every platform that comes along.
Instead of immersing yourself with every bright shiny object, do some preliminary research and determine if the platform fits with your business’ goals and objectives. Determine which channels make the most sense for you and your brand and then dominate in a smaller more focused space.
Related: Finding the Perfect Match in the Social Media Platform Universe
2. Wastes your most valuable commodity.
Entrepreneurs are busy people. It’s true.Have you ever met a self-proclaimed entrepreneur who wasn’t bearing the burden of an ever-growing to-do list?
The maddening reality is with everything you have to get done, one thing stays consistent: time taunts you every step of the way.
It has never been more important than now to capitalize on the time you can actually find, and with that comes the need to prioritize. Your priority should be set on doing the work that moves you closer to accomplishing your goals in life and business.
Chasing the latest social media platform should be assigned a priority just like any other new task that pops up in front of you. Analyze the function and utility of the platform and then determine if it directly fits your business vision. Understand if it would align with your intended audience and then figure out if you have the personal bandwidth to even attempt to engage.
Related: How to Build a Social-Media Strategy That Works
3. Being everywhere means you are nowhere fully.
When you are everywhere, you are probably nowhere for a long period of time. As a result, you lack the ability to grow and foster real relationships with your audience.
Bouncing in and out of platforms all day, or even worse becoming overly reliant on automation, actually damages your online reputation. It dilutes your brand and results in audience confusion and frustration.
Your message becomes fragmented and your community no longer knows when or where to expect your participation.
It’s much better to be a valued participant in a few select online communities than to be a part-time purveyor of occasional interaction across all.
Find the platforms that not only fit with your message but also where your audience hangs out. Then fully embed yourself in that platform and embrace as one of your core tools for driving traffic back to your website.
Today’s hyper-competitive market demands you be more than a one-trick pony. However, trying to master all will result in utilizing none to your advantage. Take inventory of your current online platform, analyze which provides the most value to your business, then set the rest aside for occasional engagement. Only when you achieve a focused approach will you truly start to see the benefits of being anywhere.

Starting the Longrich Global Business
Starting up your Longrich business is easy. There is no registration fee. Just do the following 3 steps:
1. Choose one of four Entry Levels on the right.
2. Plan your Entry Purchase so that the total product PV matches the PV required by the Entry Level of your choice.
3. Submit your particulars by filling up the Application Form or through the online registration form: http://www.longrichbioscience.com/registration.php

10 Expert Tips on Managing Cash Flow as a New Business

New startups should fully understand that running out of money is one of the primary reasons that businesses fold shortly after a launch. This scenario is a proven statistic, but startups can avoid joining the ranks of failed businesses by being smart about how they spend their startup capital.
Related: 3 Rules About Cash Flow That First-Time Business Owners Need to Know
And that's crucial: Trying to run a business without carefully managing cash flow is like trying to paddle upstream without an oar: you’re not likely to make it to your destination. Even if you do, you’ll be so exhausted you won’t have the strength to go on.
So, instead, take steps to ensure your business will be healthier. Make sure you're rowing in the direction of profit by following these 10 tips on how to manage your startup’s money.
1. Know when you’ll break even.
Knowing the point at which you’ll break even won’t necessarily impact your cash flow, but it will give you goals to strive for and a ready-made target for forecasting where your cash should go in order to reach that goal.
If you focus on that goal, and the milestones you have to hit to reach the break-even point, you’ll be smarter about how you spend your startup capital along the way, and will budget accordingly.
As Tony Hsieh , founder of Zappos, says, “Chase the vision, not the money. The money will end up following you.”
2. Keep your eye on cash-flow management.
You need to avoid focusing too heavily on profit. While that may sound like a contradiction to my first point, it’s far from it. You look at your profit and break-even point in order to set benchmarks -- but you still need to maintain focus on cash-flow and spending. That doesn’t change just because you cross over into profitability.
“Every month isn’t enough,” says Derek Flanzraich of Greatist. “Nearly every week I’m checking both my personal and business finances.”
Related: Why Your Business Needs Cash-Flow Yoga
3. Always maintain a cash reserve.
Every startup should expect shortfalls. They happen to everyone, even with the best plans in place. But your survival likely will depend on how you traverse those shortfalls. Having cash reserves for those lean times lessens the blow, the stress and the distractions, and allows you to stay focused on growing your business.
4. Manage funds better.
Unless you absolutely have to (which is rare), you shouldn’t handle the money for your business. That includes tracking it and handling your accounting. Hire an accountant or CFO to tackle this task for you. If you can’t bring on the extra help, designate a trusted employee to be a cash-flow monitor.
You can simplify this process by using a service and software platform like InDinero.com , which provides accounting software to make cash management easier. The service also provides access to accountants, CPAs and tax specialists who will work diligently to help your company grow. Having access to tax specialists is especially important to your cash flow, since they’ll make sure you stay on track with deadline dates for filing your business tax returns , to avoid penalties and interest.
5. Collect receivables immediately.
Try to make any invoices “due immediately” and limit the use of net terms longer than 15 days. If you can do so, delegate the task of keeping an eye on receivables and customer follow-up to get money in as quickly as possible.
6. Offer discounts to collect payments earlier.
If you don’t want to wait for normal net terms to pay out, then offer your customers a discount if they pay early. If employees are dealing with collections, then make sure you have guidelines that state their eligibility for discounts; and then enforce those standards strictly.
7. Extend payables where you can.
While you want to bring payments in as quickly as possible, work with your suppliers and vendors to get the best deal you can and extend payables to net 60 or more, if possible.
8. Spend only on essentials.
Part of your forecasting model should give you a strong view of the necessary expenses that are coming down the pipe. Outside of the most essential purchases, you want to minimize spending and eliminate costs that aren’t essential to your operation until you’re profitable.
9. Be smart about hiring.
I often see advice in this area that says something like, “Don’t hire until you absolutely need to.” That’s fair advice to a point, but I’m more apt to recommend smart hiring. If you can recruit top talent, a highly skilled worker is likely to be able to tackle the work of two or more mediocre employees.
You’ll probably spend a little more in salary or benefits to get that top talent, but that amount is still bound to be less than you’d spend on multiple employees covering the same task who make more frequent mistakes.
Another outcome is that they may quit on you, forcing you to start over. According to the University of California-Berkeley’s Institute for Research on Labor and Employment, it costs an average $4,000 to hire an employee. So, be smart about whom you recruit if you must hire someone.
“The secret to successful hiring is this," says Marc Benioff , CEO of Salesforce. "Look for the people who want to change the world,”
10. Make the best use of technology.
Always back up your files and cash-flow spreadsheets, to secure cloud storage . Not only will this keep your data secure from local file corruption or data loss/theft, but it will also make it easier for you to gain access from anywhere you have an Internet connection.

INTRODUCING YOU TO LONGRICH INTERNATIONAL

Please permit me to introduce to you one of the most successful multi level marketing platform in Nigeria. Please kindly take your time to read through it and do not dismiss it as one of those things.
The platform is a good one with a superb compensation plan. Suitable for a stay at home mom , yet to
be employed graduate and as a source of additional income stream to the employed
INTRODUCING YOU TO LONGRICH INTERNATIONAL
1. WHAT IS LONGRICH ALL ABOUT? Longrich is a manufacturing company with offices in 183 countries. It is ranked by Direct sales news as no 42nd of the 100 top multi level company (MLM) companies in the world and the number 1 in Nigeria. It is Chaired by Xu Zhi Wei.(most outstanding Chinese entrepreneur of the world economy).
2. WHAT PRODUCTS DO THEY HAVE? Their products include everyday consumables such as Toothpaste, cream, soap,shampoo, fruit n vegetable shakes,health wine, mouth freshener, green tea, coffee, mosquito repellent, hand cream, pad and Panty liners that treat and prevent infection, supplements like calcium, berry oil, fertility drugs for male and females, natural antibiotics, cooking pots, alkaline cups,& so many other products. All their products are therapeutic and multi functional.
3. IS THE COMPANY CREDIBLE? Longrich is over 29 years old, and has bagged loads of awards and certification from ISO, FRI, USDA organic, WHO, SGS tested, CDS, NAFDAC, ISBN. Ranked in Forbes as China’s top company.
4. HOW EFFECTIVE ARE THE PRODUCTS? The company’s wide range of products meet global standards of excellence. It maintains same or even higher quality as popular brands such as LION, Walmart, Unilever, marks n Spencer, glaxosmithkline, tesco, wool worths, Elizabeth arden, shisheido, carrefour, Estee Lauder and others. All d companies listed above are being produced for by longliqi int’l.
5. I HOPE I WILL NOT HAVE ADVERSE REACTIONS TO THE PRODUCTS? The products are formulated through careful research.The company has 8 world – class science and technology research and development (R & D) institutes in New York, Japan, France & China, with over 10000 employees, 35% of which are college students, graduate students, senior engineers,doctors and experts from numerous fields.
6. HOW DO I MAKE AN INCOME FROM THE COMPANY? By purchasing products either for personal use or for sale, by referring your friends and family to also make purchases of their daily use products from the company. There are several ways to earn from the company which are as outlined below: BONUSES 1. Performance Bonus: Your entry status as Silver is 8%, Gold is 10%, Platinum and VIP is 12% and it determines your earnings power. PB is paid weekly on all generations to infinity 2. Development Bonus: (10% flat) paid on 2 of the highest Points per level on the bonus leg. 3. Leadership .Bonus: (10% – 45%) paid on sponsorship tree up to 12th generation according to your level/ranking 4. Retail order bonus: (25%- 50%) paid on retail/repeat orders INCENTIVES 1. Platinum VIP incentive: (earn 1% of Longrich global sales every cycle, can be converted to travel/car/house. 2. Worldwide Incentive: (earned from Diamond 4 level and above)2.5% of company global sales 3: Star directors worldwide Incentive: (earn 2.5% of companies Global sale) The earnings potential in this business is huge, all that is required is DRIVE, PASSION, PERSISTENCE, ACTION.The earnings percentages increases as you move up the marketing plan unlike in other networks that it decreases, your earnings increases and explodes as your team grows, that’s why its possible for a distributor who has only been in the biz for only 6 months to earn 2m monthly, qualify for trips and cars…. Performance bonus is paid on all generations till infinity. The compensation is Superb and highly generous, and will lead to true financial freedom but you must WORK to achieve it. If you wait for a perfect condition, you will never get started, the best time to start is NOW….. No time frame (no pressure), No compulsory monthly purchases (target), Weekly bonus payment {green Thursday}, Grow at your own pace, Unlimited accumulation of bonus points, Leadership easily achieved.
7. MLM COMPANIES ARE TEDIOUS. WHAT MAKES LONGRICH DIFFERENT? Longrich has an improved model which excludes monthly compulsory injection of fresh funds, it also grows a team of 3 people as your direct downlines. Any new referral from the fourth is layered under one of the initial 3. This enhances team growth.
8. WHAT ARE IT’S ACHIEVEMENTS IN NIGERIA? In just 3 years in Nigeria, it has given out well over 100 cars to distributors across the nation, it has organised all expense paid holidays to USA, Dubai and China for more than 160 distributors. Over 5 distributors have also smiled home with houses awarded to them valued @ 25 million naira each to either purchase or build a befitting home anywhere in the world.
9. HOW CAN I BECOME A DISTRIBUTOR AND THUS BENEFIT FROM THIS GREAT OPPORTUNITY? There is no registration fee. Your purchase makes you a member. VIP, 12% - N560,000 *(earn 1% share of global sales) PLATINUM, 12% - N260,000 GOLD, 10% - N96,000 SILVER, 8% - N53,000 You are allowed to select products of your choice worth your money The catch is in achieving financial freedom through this opportunity offered by Longrich, if you decide to become a distributor. Longrich distributes its innovative products through highly motivated independent distributors using networking marketing method, but unlike other network marketing companies it offers greater profitability and flexibility.
10. BENEFITS OF LONGRICH PROMOS – Apart from bonuses paid directly into your account every week based on your team’s volume, ee have as follows : TRAVELS: The company organizes minimum of three ‘all expense paid’ international trips annually for qualifying distributors. In 2014, we had trips to Malaysia (FEB), USA (AUG) and China (DEC). In 2015 and 2016 , there were trips to Europe (France, Germany,Switzer land, Italy), Dubai, Ghana, USA, China. CAR: There is a yearly Car promo which is currently running now from January 2016 to January 2017. LONGRICH has awarded over 100 brand new cars within its first 3 years! HOUSE: 25 Million house money is awarded from Star Director level You are simply expected to bring in 3 people when you join, with the support offered by the team/club, those 3 people are taught , trained and encouraged to each duplicate to get their own 3, the business is fun, extremely exciting and rewarding.
I must state that LONGRICH is not a get rich quick scheme. With commitment and hard work ,associating with longrich will change your financial fortunes forever.
For more information, kindly call us on 08062991184, WhatsApp on

6 Qualities of Successful People
1. They are ambitious.
They see themselves capable of being the best. They see themselves with the capacity of being really good at what they do.
This was a really big thought for me. It held me back for many years. When I saw people who were doing better than I was, I naturally assumed they were better than I was. And if they were better than I was, then I must be worse than them. So that would mean they were superior and I was inferior.
Related: Rohn: 4 Keys to Unlock the Power of Your Mind
That’s a big problem in our society—we have
feelings of inferiority , and these feelings of inferiority are often translated into feelings of undeservedness. The word “deserve” comes from two Latin words meaning “from service.” You deserve 100 percent of everything you make and enjoy as long as you get it from serving other people. If you serve better and serve more and serve at a higher level and serve more enthusiastically and serve a higher quality, then you’ll have a wonderful income—and you’ll deserve every penny of it.
You just must see yourself capable of being the best .
2. They are courageous.
Successful people work to confront the fears that hold most people back. The two biggest enemies to our success are fear and doubt.
When you do something repeatedly, you develop a habit. Make a habit throughout your life of doing the things that scare you. If you do the thing you fear, the death of fear is certain.
So face your fear. The ability to confront your fear is the mark of the superior person. If you have high ambition and you decide to be at the top, and you can confront your fears and do the things that are holding you back, those two things alone will make you a great success.
3. They are committed.
The top people in every field are completely committed. They believe in themselves; they believe in their companies; they believe in their products and services; they believe in their customers. They have an intense belief .
We know that there is a one-to-one relationship between the depth of your belief and what happens in your reality. And if you absolutely believe in the rightness and the goodness of what you’re doing, you become like a catalyst. You create what is called a transfer, like an electrical transfer of enthusiasm.
People who are not committed to what they do lead very empty lives. Caring is a critical element in life—all men and women who enjoy great lives care about what they do. They have passion about what they do. They love what they do.
Related: 3 Ways to Improve Your Willpower and Stop Procrasting
4. They are prepared.
Successful people review every detail in advance. They do things that the average person is not willing to do. They make sacrifices the average person is not willing to make. But the difference it makes is extraordinary.
Before you go into a meeting, do your homework. Before you give a speech , research the information and practice your talking points. Dive in deep to review every detail of every situation before you take it on.
Successful people are more concerned about pleasing results than they are about pleasing methods. There is nothing more complimentary to your team, your client, your audience than the feeling that you have thoughtfully prepared.
5. They are continuous learners.
High achievers recognize that if they’re not continually getting better, they’re getting worse. They read, they listen to CDs and they take additional training. The professional never stops learning. So read, listen to CDs and take continuous training.
Never stop learning.
6. They are responsible.
The top people in our society have an attitude of self-employment. That’s essential, because 100 percent of us are self-employed—we are presidents of our own personal services corporation. You work for yourself, and the biggest mistake we can ever make is to think we work for anyone else. The person who signs our paycheck may change, our jobs may change, but we are always the same. We are the one constant.
The fact of the matter is that this is not optional—it is mandatory. You’re the president of your own career, your own life, your own finances, your own body, your own family, your own health. You are totally responsible.
We have to be responsible. No one will ever do it for us. It’s the most liberating and exhilarating thought of all, to think, to realize, that you’re the president of your own life.